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Since VIP is ineffective at stimulating gland secretion in CF, then it seems an unlikely candidate to mediate the increased muc5B concentrations (which is largely expressed in the glands and to a lesser extent in surface goblet cells [134]) that are observed during CF exacerbations [135]

Environ Exp Bot 161:425 Sun Y, Li L, Macho AP, Han Z, Hu Z, Zipfel C (2013) Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex

Hence, the finding of slow colonic transit does not exclude the diagnosis of DD

Bioactive fraction of Rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats